Esterides can cause in the child premature closing of epfisises, produce ginecomastia or cause flowery virilizao, as well as causing virilizao in the woman. They can act on the heptica function, taking to colestase with increases of transaminases and bilirubins. Sam Mikulak wanted to know more. This action depends on previous injury of the liver. Study in athlete with anablicos current and previous use of esterides, it found significant increase of transaminase oxaloactia (YOU), transaminase glutamicopirvica (TGP) and LDL HDL-cholesterol cholesterol and reduction. levels were modified in the athletes with current use of the drug, but none presented clinical manifestation.
The athletes who had made previous use had normal examinations, showing that the damage to hepatocelular is acute and ceases with the interruption of the drug. Esterides anablicos produces dramatical reduction of the HDL-cholesterol levels, and this reduction does not seem to become related with the dose, in view of that it can occur in therapeutical doses. The athletes in current use of esterides, can present lower HDL-cholesterol, showing bigger risk of ischemic illness (LABREE, 1991; WILSON, 1993). Estanozolol diminishes apolipoproteina and A-II THERE, while it increases apolipoproteina B and D. A probable involved mechanism is the induction of the activity of the HTLG- lipase triglicride endotelial heptica, a time that its levels increase 227 232% with estanozolol and 100% with oxandrolona.
This enzyme cataboliza HDL saw activity of fosfolipase and participates of hydrolysis of HDL2 for HDL3. The reduction of the HDL2 has greater relation with the coronariano risk. Research with comparisons evidences that it has reduction in the HDL-cholesterol, it occurs, however, reduction of the LDH, reduction of the levels of triglicrides and reduction of the total cholesterol. Although the reduction of the HDL, the concomitant reduction of the other lipdicas fractions, seem if comtrapor to the increase of the risk of coronariana illness.